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Microemulsion Supramolecular Gels for Protein Modulated Hydrophilic/Hydrophobic Dual-drug Delivery  
Microemulsion Supramolecular Gels for Protein Modulated Hydrophilic/Hydrophobic Dual-drug Delivery
資料類型: PDF文件
關(guān)鍵詞: Microemulsion  supramolecular  gels  Dual-drug  delivery  Protein  modulated  
資料大?。?/td> 105K
所屬學(xué)科: 分子表征
來源: 第六屆亞歐研討會(huì)上處理和性能增強(qiáng)聚合物會(huì)議文集(2013.6.2-6 武漢)
簡(jiǎn)介:
Mutil-drugdeliverysystemcanimprovetheefficiencyofthetreatmentofdiseases.Inthiswork,amicroemulsionsupramoleculargeI(MSG)wasdevelopedasdualdrugreleasedeliverysystem.Themicroemulsionconsistsofisopropylmyristate,Tween80,propyleneglycolandPBS;andl,3:2,4-di-O-benzylidene-D-sorbitol(DBS)wasusedforgelationthemicroemulsion.5-aminosalicylicacid(5-ASA)andcurcumin(Cur)wereemployedasdual-drugmodelfortheinvestigationofproteinmodulatedreleasebehaviorinthisdeliverysystem.DSCanddyesolubilitytestsshowedthatthepreparedmicroemulsionisbicontinuous;SEMimagesrevealedthatMSGhasathree-dimensionalnetwork.RheologicalmeasurementsrevealedthatMSGexhibitsawell-developednetworkandtheadditionofdualdrugexertsnoeffectonthetheologicalpropertiesofMSG.Theresultsindicatedthatthedualdrugreleasebehaviorcanbemodulatedbybovineserumalbumin(BSA).AtpH7.4,BSArestrainedthereleaseofdualdrug.WhenDBSconcentrationisl.5wt%,atpH7.4,thereleaseratesof5-ASAandCurdecreased14.46%and3%withthepresenceof0.5mg/mLBSArespectively.However,inacidicmedia(pHl.2)andweakacidicmedia(pH5.8andpH6.8),BSAcouldpromotethereleaseratesofdualdrug.AtpH5.8,thereleaseratesof5-ASAandCurincreased17.08%and7.62%withthepresenceofl.0mg/mLBSArespectively.TheseresultsrevealedthatMSGasaquicklyresponsetotheenvironmentstimulationdeliverysystemshaspotentialapplicationinmutil-drugrelease.
作者: W. Li , Y. J. Yang, H. Wang
上傳時(shí)間: 2013-07-04 14:07:45
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