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Preparation of Highly Porous and Interconnected Scaffold by the Combination of Particulate Leaching and Supercritical C02 Foaming  
Preparation of Highly Porous and Interconnected Scaffold by the Combination of Particulate Leaching and Supercritical C02 Foaming
資料類型: PDF文件
關(guān)鍵詞: tissue  engineering  scaffold  supercritical  c02  porous  agent  
vane  extruder  
資料大小: 104K
所屬學(xué)科: 分子表征
來源: 第六屆亞歐研討會上處理和性能增強聚合物會議文集(2013.6.2-6 武漢)
簡介:
ThisstudyistoprepareporousscaffoldsbyusingvaneextruderandevaluatethefeasibilityofapreparationmethodofcombiningparticulateleachingandsupercriticalC02foamingtechniquesforthepreparationofhighlyinterconnectedthree-dimensionalpolymericporousscaffolds.Inthefirststepofthistechnique,polyvinylalcohol(PVOH)actingasporeagentwascompositewithpolylacticacid(PLA)byusingvaneextruder.Toformco-continuousmorphology,thevolumeratioofPVOHwaskeptabove50%,thenwatersolublepolymerPVOHwasextracted.Themaximumporosityisupt070%,yettheporesizeisdifficulttocontrol.Amountofsodiumchloridesaltwasaddedactedassecondaryporeagent,whichiseasytocontrolporesize.Inthisstudy,twokindsofsaltparticlesizerangewereused,38一75ymand75~150ym.TheporesizeinthescaffoldsiscontrolledbysaltparticulatesandinterconnectivityisachievedbythewatersolublePVOH.Scanningelectronmicroscopyandthermogravimetricanalyzerwereinvestigatedtheeffectofsaltparticlessizeonmixinguniformityandporemorphology.Theresultsindicatedthatsmallerparticlesizeisadvantagetoformhighlyinterconnectedporesanduniformdistribution.Inordertoincreasetheporosity,supercriticalC02foamingwasintroduced.Thepreparedscaffoldshaverelativelyhomogeneousporestructureandtheporositycanbeupt085%.
作者: B. Y. Chen, P. Yu, H. B. Zhao, W. H. Zhang, X. F. Peng
上傳時間: 2013-07-02 15:56:39
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